Accomplishments to Date & the Future

There are two major challenges to clearing senescent cells using our approach.

  • First is to design and create the DNA construct that recognizes that a cell has become senescent, and then destroys it.
  • Second is to safely and efficiently deliver this construct into cells throughout the body.

Both goals have been achieved in our pioneering Proof of Concept experiments in 2016.

We’ve first demonstrated the ability to transduce cells both in vitro (cell culture) and in vivo (in aged mice). Then we showed that p16 positive senescent cells can be killed on demand in both in vitro and in vivo environments. Now we are embarked on experiments that will show improvements in both healthspan and lifespan in model organisms from mice to primates. And then, everything changes.